Purpose The lecture is a time efficient educational platform designed to deliver a large volume of content with a passive student approach. To improve upon this educational tool, the lecture will have a patient centered approach covering history of present illnesses, physical and laboratory data and delivery of the basic and clinical sciences content. Relevant board-style questions will be incorporated within the lecture. The integrated basic and clinical science content will be structured around cases which could develop into additional complicated cases. Methods Lecture will be 20-30 minutes with another 20 minutes for student participation. For example, a lecture titled “Form, Function and Dysfunction of The Extrahepatic Biliary System” starts with an acute cholangitis in a case presentation with several questions. The lecture incorporates the basic and clinical sciences of the extrahepatic biliary system. Patient signs and symptoms are discussed with laboratory and imaging findings. The anatomy, histopathology and pathophysiology are delivered. The science content is delivered from an integrated format allowing for an opportunity for faculty development overcoming professional silos. Results The medical students will be assessed on the questions within the lecture along with weekly assessment quizzes and biweekly in-house exams. The final exam will be a customed NBME exam. The students will also be assessed with a participation rubric. Purpose The new format of the lecture will deliver the basic and clinical science content within the format of a physician’s approach to patient management. Medical students will better appreciate the basic science foundation of the clinical cases developed within the lecture. This lecture format allows for basic science and clinical educators to develop new lecture formats integrating basic and clinical content overcoming professional silos.