This talk is presented by Professor Stuart Reece who together with Professor Gary Hulse has published many cutting edge papers recently on the epidemiology of cannabinoids and indeed the team continues to publish actively in this field. Numerous cannabinoids have been known to be genotoxic by many mechanisms for fifty years with damage to DNA, chromosomes, the epigenome and the metabolism on which genetic and epigenetic health are based all being well documented. This talk presents an overview of the epidemiology of cannabinoid genotoxicity as it relates to cancer and congenital anomaly data from the USA and Europe and elsewhere using advanced statistical techniques and the formal tools of causal inference to report not just associations but the quantitative criteria of epidemiological causal relationships. One particular feature is reproductive and inheritable benign and malignant genotoxic outcomes. The talk also focuses on the close relationship between laboratory-demonstrated genotoxicity with patterns of malignant and inherited disease amongst human populations. The implications for population health of widespread genotoxicity applied generally through the food chain for cellular and human aging across human populations based on the latest research developments is then considered. In all analyses, cannabinoids are shown to be much more genotoxic than tobacco or alcohol. Collectively these several large datasets strongly indicate that populations need to be carefully protected from pleiotropic cannabinoid genotoxicity in line with public health policies relating to all other potent genotoxins.