U.S. Medical Schools are significantly changing curricula to meet the evolving needs of health systems by incorporating more Health Systems Science into their programs.  Although much progress has been made over the past several years, significant challenges remain.  The successful implementation of HSS is challenging due to the need for new curricula, novel assessments and evaluations within the workplace, the development of educators, resource allocation, and the receptivity and engagement by students and faculty in this learning agenda.  In this session, the facilitators will articulate several of the key challenges facing Health Systems Science education, and suggest strategies to address these challenges.  To fulfill the obligation of preparing the next generation of systems-ready physicians, the medical education community must develop a shared understanding of these challenges to catalyze change.