In 2012 Bradford School of Pharmacy and Medical Sciences transitioned an entire 4-year pharmacy program from a traditional didactic model to one delivered predominantly by Team-Based Learning. This involved a major curricular redesign, a change management process, winning the hearts and minds of 70 faculty members, and persuading administrators, students and colleagues that the benefits would outweigh the challenges. 12-years on we reflect on the lessons learned, the challenges we overcome, and the opportunities it afford us along the way.