As higher education pivots toward student-centered models, the integration of structured pedagogical frameworks is critical for fostering deep learning and professional competency. Drawing upon over a decade of longitudinal research, this presentation examines the intersection of Team-Based Learning (TBL) and flipped teaching as a catalyst for optimizing student engagement and performance. Central to this discussion is the "modified TBL" (mTBL) approach, which utilizes Individual and Team Readiness Assurance Tests (iRAT and tRAT) to enforce accountability and catalyze collaborative problem-solving. This study further investigates how the strategic embedding of retrieval practice within these frameworks strengthens long-term retention and provides faculty with a robust mechanism to mitigate common implementation barriers. By analyzing documented outcomes and faculty perceptions across diverse contexts—including undergraduate STEM and professional graduate programs—this session presents empirical evidence that these high-impact practices significantly improve learning gains and support seamless transitions to hybrid or online environments.