Curricular reforms in medical education have promoted enhanced integration of basic and clinical science to promote transfer of knowledge into practice. While integration has been modestly successful in pre-clerkship curricula, incorporating basic science into the clerkships remains a perplexing challenge. This session will highlight innovative instructional and assessment strategies that are designed to encourage integration of the basic sciences during clerkships. The session will also discuss emerging data concerning learner perceptions of basic science integration, noting opportunities and barriers.