Artificial intelligence (AI) is disrupting practices of health care delivery and health professions education. Successful incorporation of AI for the benefit of patients and communities requires health professionals trained to adeptly and critically apply AI tools. This necessitates a shift in some elements of professional identity and will force transformation of health professions education. It is essential that educators are informed about the promise and perils of AI to actively guide responsible use of these tools by and for learners facing a rapidly evolving practice environment.