1. The endocannabinoid system in the body is a primary target of THC, the key cannabinoid in marijuana:
-what is the endocannabinoid signaling system?
-where is it localized?
-what are its functions?

2. How do THC and endocannabinoids act?
-what are phytocannabinoids (compounds made by plants)?
-what are THC actions in the body? (receptor targets in brain, peripheral tissues)
-do THC and opioid signaling systems crosstalk?
-do actions by THC (plant-derived) or endocannabinoids (made by brain) differ?
-does THC affect neurodevelopment?
-medical marijuana and recreational marijuana; do they differ?

3. What are the consequences of THC actions?
-does THC engender neuroadaptive changes?
-are the effects of THC related to dose and frequency of use?
-what are short- and long-term implications of marijuana?