The pandemic has required educators to adapt their pedagogies, methodologies, and learning environments suddenly and gradually. We have learned that a 'One Size Fits All' approaches often yields 'One Size Fits None' realities. The on-going challenge is to design simultaneously for in-person, online, synchronous, and asynchronous learners to provide flexibility for all learners to participate actively. At the University of Colorado's Center for Interprofessional Practice & Education (CUCIPE) we created an inclusive environment for students accessing group learning in a variety of ways. Our innovative course design supports a cohort of ~800 health professions students. This fall, we will refine the approach using a Hybrid-Flexible (HyFlex) course model. The fundamental values of HyFlex design include: 1) Learner Choice, 2) Equivalency, 3) Reusability, and 4) Accessibility. Successful HyFlex systems require shared definitions of learner types mapped to agreed policies and procedures for In-Person, Remote, Flex, and/or Asynchronous learners. This will enable us to adapt quickly to any exceptions that arise