This presentation examines health disparities in Appalachia, WV, and their interplay with societal and cultural dynamics. It explores how socio-cultural factors, including education, employment, and environment, impact health outcomes in a region grappling with chronic diseases, limited healthcare, and an opioid crisis. The talk emphasizes preserving Appalachian culture and society while addressing public health challenges. Case studies highlight issues like opioid addiction and respiratory diseases, showcasing the region's cultural resilience. Public health initiatives and GIS analysis of health disparities focus on culturally sensitive solutions. Strategies such as telemedicine and community health programs are proposed, respecting Appalachian cultural values. The presentation concludes with a call for efforts to foster a healthier, culturally preserved Appalachia.