Health Systems Sciences has evolved as the third pillar of medical education, integrated with the two historic pillars—basic and clinical sciences. To address this curricular innovation, the Spring 2020 IAMSE webcast audio seminar series will explore the implementation of Health Systems Science (HSS) curricula in medical education. Experts and thought leaders will discuss curricular efforts to incorporate HSS in both the pre-clerkship and clerkship years as well as residency. Specifically, after an introduction, the audience will learn about the goals and objective of HSS curricula, and become familiar with the challenges, obstacles and feasibility as well as current curricular programs and efforts. Curricular strategies in UME, both pre-clerkship and clerkship will be presented with hands-on detail including challenges of integration with basic and clinical sciences and assessment. At the end of the seminar series, the audience will be able to design and implement an HSS curriculum at their own institutions.